The unnamed woman was reported to have been crossing the road when she was struck. Despite being rushed to hospital, she later died from her injuries.
Reports indicate while a driver was present behind the wheel, the car was in autonomous mode at the time of the collision. No passengers were in the Uber when the collision occurred.
Uber has suspended all trials of self-driving cars in light of the incident. The company has been running a fleet of autonomous vehicles across various locations in North America, including Pittsburgh, Toronto and San Francisco.
A brief statement released by the company said: "Our hearts go out to the victim’s family. We are fully cooperating with local authorities in their investigation of this incident."
A statement released by Tempe police described the incident further: "The vehicle involved is one of Uber's self-driving vehicles. It was in autonomous mode at the time of the collision, with a vehicle operator behind the wheel.
"The vehicle was traveling northbound just south of Curry Rd. when a female walking outside of the crosswalk crossed the road from west to east when she was struck by the Uber vehicle. She was transported to a local area hospital where she passed away from her injuries. Her next of kin has not been notified yet so her name is not being released at this time. Uber is assisting and this is still an active investigation."
The crash follows a fatal accident in May 2016, when the driver of a Tesla Model S in Autopilot semi-autonomous mode died after his car collided with a lorry. Investigations indicated the Tesla's Autopilot system failed to differentiate between the truck’s white trailer and a bright sky.
This latest crash is the first time a pedestrian has been reported killed in an accident involving an autonomous car, however, and is likely to cause policymakers to look closely at future legislation that allows self-driving car testing on public roads.
Earlier this month, the UK Government announced a wide-ranging legal review into self-driving cars, with a view to investigating how ““current driving laws can support the next generation of vehicles.”