Sinovac showed efficacy of 50.4%

[Ender]

16 hours ago, Falc said:

There could be a crucial difference in this comparison (your last sentence) - no delta variant in their 3rd wave. Widely accepted that delta is more infectious but less lethal? 

So this is not a fair comparison, on one side we have the presence of the high proportion of vaccinated, then on the other side we have the absence of the delta variants.

Have two input variables that have opposing effects on the dependant variable (number of cases), we cannot make a firm conclusion.

[Lala81]

Tough for countries relying purely on Sinovac.

https://www.channelnewsasia.com/news/asia/indonesia-report-doctor-deaths-covid-19-july-delta-variant-15244408

Quote

A total of 114 doctors died during Jul 1 to Jul 17, the highest number reported for any period of similar length and more than 20 per cent of the 545 total doctor deaths from COVID-19 since the beginning of the pandemic, officials from Indonesia's doctors association (IDI) said during a virtual news conference.

Mahesa Paranadipa, a senior IDI official, said the association was concerned that the medical system may not be able to cope, according to a recording of the event.

"We are worried about the potential of a functional collapse," Paranadipa said. "This is the reported data, not yet data that may not have been reported to us."

Doctors' deaths have increased in Indonesia, the world's fourth most-populous nation, despite a 95 per cent vaccination rate among health workers. This has prompted the government to use a batch of Moderna vaccines as booster shots to China's Sinovac for healthcare workers.

 

Edited July 18, 2021 by Lala81

[Flying_genie]

6 hours ago, Vinyl said:

Is this supposed to be funny? What is the purpose of this post?
I am sorry but I have to say I disagree with this message that you are sharing.

[pi3142]

Pre-print though.

Progressive Increase in Virulence of Novel SARS-CoV-2 Variants in Ontario, Canada

https://www.medrxiv.org/content/10.1101/2021.07.05.21260050v2
 

Quote

Methods: We created a retrospective cohort of people in Ontario testing positive for SARS-CoV-2 and screened for VOCs, with dates of test report between February 7 and June 22, 2021 (n=211,197). We constructed mixed effects logistic regression models with hospitalization, ICU admission, and death as outcome variables. Models were adjusted for age, sex, time, comorbidities, and pregnancy status. Health units were included as random intercepts.

Results: Compared to non-VOC SARS-CoV-2 strains, the adjusted elevation in risk associated with N501Y-positive variants was 59% (49-69%) for hospitalization; 105% (82-134%) for ICU admission; and 61% (40-87%) for death. Increases with Delta variant were more pronounced: 120% (93-153%) for hospitalization; 287% (198-399%) for ICU admission; and 137% (50-230%) for death.

 

 

Edited July 18, 2021 by pi3142

[inlinesix]

3 minutes ago, pi3142 said:

Pre-print though.

Progressive Increase in Virulence of Novel SARS-CoV-2 Variants in Ontario, Canada

https://www.medrxiv.org/content/10.1101/2021.07.05.21260050v2

Not PEER review yet

[Vinyl]

2 hours ago, Flying_genie said:

Is this supposed to be funny? What is the purpose of this post?
I am sorry but I have to say I disagree with this message that you are sharing.

Another 🤡 对号入座 

[Falc]

18 hours ago, Vinyl said:

Remember last year? Summer time the Western world thought they managed to bend the curve and then the colder seasons came. They celebrated early, they enjoyed their festive seasons.

This year, with vaccinations, I'll expect things to be better, but you never know?

Worse come to worst, blame China?

I think if waves still come, the blame will fall on the unvaccinated. It's too late to blame China now. But let not history be whitewashed! 

[Falc]

15 hours ago, Lala81 said:

Don't recall any data saying Delta is less lethal. I don't think any strong evidence that it is more lethal also. 

At least no mention so far. Just very transmissible. 60% more than alpha (which itself is 70% more than the original strain in Europe/USA).

The Reassuring Data on the Delta Variant https://www.wsj.com/articles/delta-variant-hospitalizations-covid-coronavirus-vaccine-immunity-11626374706

U.S. hospitalization data also show not only that higher Delta prevalence doesn’t go hand in hand with higher hospitalization rates; these numbers appear inversely correlated—that is, places that had higher percentages of the Delta variant had lower ratios of hospitalized people to Covid cases. Whatever else we know or don’t know about Delta, its prevalence clearly isn’t driving hospitalizations. When we look at current hospitalization data across the country, the most striking predictive pattern is that a high vaccination rate in a region accurately predicts a lower hospitalization rate. 

 

Lower hospitalization rate could be due to vaccination as well. The study didn't seem to separate the cases by vaccination and non vaccination. 

[Kb27]

Sinopharm's COVID-19 shot induces weaker antibody responses to Delta -study

BEIJING (Reuters) - Sinopharm's COVID-19 vaccine elicited weaker antibody responses against the Delta variant, based on the first published study of its effect against the more contagious version.

Antibody levels in people receiving Sinopharm's BBIBP-CorV vaccine had a 1.38-fold reduction to the Delta variant versus an older version of the coronavirus first identified in Wuhan, a lab study based on samples from people in Sri Lanka showed.

The study was conducted by scientists from University of Sri Jayewardenepura as well as Colombo Municipal Council in Sri Lanka, and University of Oxford in the United Kingdom.

The Delta variant, first found in India late last year, has since become the dominant version of the virus worldwide and is behind a recent surge in infections reported in many countries including Britain, Indonesia, the United States and South Korea. It has been detected in more than 90 nations worldwide.

The vaccine from Sinopharm, formally China National Pharmaceutical Group, also showed a more pronounced 10-fold decrease in antibody levels to the Beta variant, first found in South Africa, the study, published on Monday ahead of peer review, showed.

Researchers said they found no significant difference in levels of antibodies to the two variants from blood serum of vaccinated people compared with the serum of those who had been naturally infected.

This suggested that Sinopharm's vaccine may be able to induce antibody-based responses against the two variants similar to the levels seen following natural infection, the paper said.

The two-dose vaccine is one of the most widely used COVID-19 shots in China, and Sinopharm agreed to provide up to 170 million doses to the global vaccine sharing scheme COVAX through to the middle of 2022.

[Didu]

Please don't call it "Pfizer-BioNTech" vaccine when you're in China. Just refer to it as "BNT162b2" to keep the AMDK name out.  😁

China to approve mRNA Covid-19 vaccine soon

China's drug regulator is set to give the green light for the first foreign-made mRNA vaccine. Shanghai-based Fosun Pharma said the National Medical Products Administration (NMPA) recently completed an expert panel review of an mRNA Covid-19 vaccine co-developed between the company and German firm BioNTech. Named BNT162b2, the vaccine is internationally known as the Pfizer-BioNTech vaccine, or by its brand name, Comirnaty, which is being administered in many countries around the world, including Singapore. In China, it is referred to as the Fosun-BioNTech vaccine.

Last week, Fosun said BNT162b2 was now undergoing an administrative review, and company chairman Wu Yifang told a shareholders meeting that the drugmaker was targeting to start domestic trial production by the end of August. Caixin news magazine, citing sources close to the NMPA, said regulators were looking at administering BNT162b2 to those who have been fully vaccinated as a booster. It is unclear who will be given priority for the booster shots.

Most of the Chinese-developed vaccines, which are on an inactivated virus, have lower published efficacy rates than the others developed overseas, including Pfizer-BioNTech and AstraZeneca. Meanwhile, the National Health Commission (NHC) in its daily update said that as at Tuesday, 1.4 billion doses of Covid-19 vaccines had been administered in China.

But as the nationwide vaccination programme continues with four domestically produced jabs, the top health authority has found itself having to repeatedly rein in local officials who have arbitrarily enacted rules to get residents vaccinated, contradicting central policy that states that they should be voluntary. The rules included barring children of unvaccinated individuals from going to school and denying public and medical services to those who had not received their shots.

"Those who are not yet inoculated should hurry and get jabbed to avoid affecting your child's return to school," said a notice in western Guangxi province. 

Similar pronouncements surfaced in Jiangxi and Henan, while Hancheng in central Shaanxi province said unvaccinated people could not enter restaurants or entertainment venues. This was the second time this year that the central government has had to rein in local authorities. Earlier this year, a township in the southern province of Hainan similarly tried to implement compulsory vaccination, barring those who had not done so from taking public transport and entering restaurants.  The policy was later reversed, with the government apologising. The incidents highlight the challenge China faces in trying to reach herd immunity while ensuring that a relatively new vaccine is not simply imposed on the population.  It is also indicative of the difficulties in implementing national policies at a local level.  This is especially when officials' performance evaluations are tied to barometers such as vaccination rates and even efficiency in controlling the virus outbreak, said Assistant Professor Gao Jie at the National University of Singapore's Department of Political Science, who researches local governments in China. For instance, several senior officials in Beijing and Yunnan were replaced after a resurgence of Covid-19 cases late last year and earlier this year.

"In the actual implementation process, local officials need to strike a balance between what the upper levels expect and what they can deliver with the resources at their disposal," Prof Gao told The Straits Times. "Sometimes, the manner in which grassroots-level officials implement the policies paradoxically undermines the national goal."

https://www.straitstimes.com/asia/east-asia/china-to-approve-mrna-vaccine-soon

[Lala81]

17 hours ago, Kb27 said:

Sinopharm's COVID-19 shot induces weaker antibody responses to Delta -study

BEIJING (Reuters) - Sinopharm's COVID-19 vaccine elicited weaker antibody responses against the Delta variant, based on the first published study of its effect against the more contagious version.

Antibody levels in people receiving Sinopharm's BBIBP-CorV vaccine had a 1.38-fold reduction to the Delta variant versus an older version of the coronavirus first identified in Wuhan, a lab study based on samples from people in Sri Lanka showed.

The study was conducted by scientists from University of Sri Jayewardenepura as well as Colombo Municipal Council in Sri Lanka, and University of Oxford in the United Kingdom.

The Delta variant, first found in India late last year, has since become the dominant version of the virus worldwide and is behind a recent surge in infections reported in many countries including Britain, Indonesia, the United States and South Korea. It has been detected in more than 90 nations worldwide.

The vaccine from Sinopharm, formally China National Pharmaceutical Group, also showed a more pronounced 10-fold decrease in antibody levels to the Beta variant, first found in South Africa, the study, published on Monday ahead of peer review, showed.

Researchers said they found no significant difference in levels of antibodies to the two variants from blood serum of vaccinated people compared with the serum of those who had been naturally infected.

This suggested that Sinopharm's vaccine may be able to induce antibody-based responses against the two variants similar to the levels seen following natural infection, the paper said.

The two-dose vaccine is one of the most widely used COVID-19 shots in China, and Sinopharm agreed to provide up to 170 million doses to the global vaccine sharing scheme COVAX through to the middle of 2022.

It's the same with all vaccines. Weakest against beta. Weaker against delta. 

[Volvobrick]

20 minutes ago, Didu said:

Please don't call it "Pfizer-BioNTech" vaccine when you're in China. Just refer to it as "BNT162b2" to keep the AMDK name out.  😁

China to approve mRNA Covid-19 vaccine soon

China's drug regulator is set to give the green light for the first foreign-made mRNA vaccine. Shanghai-based Fosun Pharma said the National Medical Products Administration (NMPA) recently completed an expert panel review of an mRNA Covid-19 vaccine co-developed between the company and German firm BioNTech. Named BNT162b2, the vaccine is internationally known as the Pfizer-BioNTech vaccine, or by its brand name, Comirnaty, which is being administered in many countries around the world, including Singapore. In China, it is referred to as the Fosun-BioNTech vaccine.

Last week, Fosun said BNT162b2 was now undergoing an administrative review, and company chairman Wu Yifang told a shareholders meeting that the drugmaker was targeting to start domestic trial production by the end of August. Caixin news magazine, citing sources close to the NMPA, said regulators were looking at administering BNT162b2 to those who have been fully vaccinated as a booster. It is unclear who will be given priority for the booster shots.

Most of the Chinese-developed vaccines, which are on an inactivated virus, have lower published efficacy rates than the others developed overseas, including Pfizer-BioNTech and AstraZeneca. Meanwhile, the National Health Commission (NHC) in its daily update said that as at Tuesday, 1.4 billion doses of Covid-19 vaccines had been administered in China.

But as the nationwide vaccination programme continues with four domestically produced jabs, the top health authority has found itself having to repeatedly rein in local officials who have arbitrarily enacted rules to get residents vaccinated, contradicting central policy that states that they should be voluntary. The rules included barring children of unvaccinated individuals from going to school and denying public and medical services to those who had not received their shots.

"Those who are not yet inoculated should hurry and get jabbed to avoid affecting your child's return to school," said a notice in western Guangxi province. 

Similar pronouncements surfaced in Jiangxi and Henan, while Hancheng in central Shaanxi province said unvaccinated people could not enter restaurants or entertainment venues. This was the second time this year that the central government has had to rein in local authorities. Earlier this year, a township in the southern province of Hainan similarly tried to implement compulsory vaccination, barring those who had not done so from taking public transport and entering restaurants.  The policy was later reversed, with the government apologising. The incidents highlight the challenge China faces in trying to reach herd immunity while ensuring that a relatively new vaccine is not simply imposed on the population.  It is also indicative of the difficulties in implementing national policies at a local level.  This is especially when officials' performance evaluations are tied to barometers such as vaccination rates and even efficiency in controlling the virus outbreak, said Assistant Professor Gao Jie at the National University of Singapore's Department of Political Science, who researches local governments in China. For instance, several senior officials in Beijing and Yunnan were replaced after a resurgence of Covid-19 cases late last year and earlier this year.

"In the actual implementation process, local officials need to strike a balance between what the upper levels expect and what they can deliver with the resources at their disposal," Prof Gao told The Straits Times. "Sometimes, the manner in which grassroots-level officials implement the policies paradoxically undermines the national goal."

https://www.straitstimes.com/asia/east-asia/china-to-approve-mrna-vaccine-soon

 

Those unvaccinated there maybe waiting for Western vaccines, here some are waiting for Chinese vaccines.  Same same don't trust own gahmen....

But good news indeed - China should recognise my Pfizer vaccine cert for future travel!

 

 

Edited July 22, 2021 by Volvobrick

[Didu]

5 minutes ago, Volvobrick said:

Those unvaccinated there maybe waiting for Western vaccines, here some are waiting for Chinese vaccines.  Same same don't trust own gahmen....

But good news indeed - China should recognise my Pfizer vaccine cert for future travel!

When it comes to the Chinese govt recognising, it may become very sensitive and drift away from the realm of science. 

[Jamesc]

Western vaccines are rubbish.

I only trust China vaccines.

For my MIL.

[Soya]

18 hours ago, Didu said:

Please don't call it "Pfizer-BioNTech" vaccine when you're in China. Just refer to it as "BNT162b2" to keep the AMDK name out.  😁

China to approve mRNA Covid-19 vaccine soon

China's drug regulator is set to give the green light for the first foreign-made mRNA vaccine. Shanghai-based Fosun Pharma said the National Medical Products Administration (NMPA) recently completed an expert panel review of an mRNA Covid-19 vaccine co-developed between the company and German firm BioNTech. Named BNT162b2, the vaccine is internationally known as the Pfizer-BioNTech vaccine, or by its brand name, Comirnaty, which is being administered in many countries around the world, including Singapore. In China, it is referred to as the Fosun-BioNTech vaccine.

Last week, Fosun said BNT162b2 was now undergoing an administrative review, and company chairman Wu Yifang told a shareholders meeting that the drugmaker was targeting to start domestic trial production by the end of August. Caixin news magazine, citing sources close to the NMPA, said regulators were looking at administering BNT162b2 to those who have been fully vaccinated as a booster. It is unclear who will be given priority for the booster shots.

Most of the Chinese-developed vaccines, which are on an inactivated virus, have lower published efficacy rates than the others developed overseas, including Pfizer-BioNTech and AstraZeneca. Meanwhile, the National Health Commission (NHC) in its daily update said that as at Tuesday, 1.4 billion doses of Covid-19 vaccines had been administered in China.

But as the nationwide vaccination programme continues with four domestically produced jabs, the top health authority has found itself having to repeatedly rein in local officials who have arbitrarily enacted rules to get residents vaccinated, contradicting central policy that states that they should be voluntary. The rules included barring children of unvaccinated individuals from going to school and denying public and medical services to those who had not received their shots.

"Those who are not yet inoculated should hurry and get jabbed to avoid affecting your child's return to school," said a notice in western Guangxi province. 

Similar pronouncements surfaced in Jiangxi and Henan, while Hancheng in central Shaanxi province said unvaccinated people could not enter restaurants or entertainment venues. This was the second time this year that the central government has had to rein in local authorities. Earlier this year, a township in the southern province of Hainan similarly tried to implement compulsory vaccination, barring those who had not done so from taking public transport and entering restaurants.  The policy was later reversed, with the government apologising. The incidents highlight the challenge China faces in trying to reach herd immunity while ensuring that a relatively new vaccine is not simply imposed on the population.  It is also indicative of the difficulties in implementing national policies at a local level.  This is especially when officials' performance evaluations are tied to barometers such as vaccination rates and even efficiency in controlling the virus outbreak, said Assistant Professor Gao Jie at the National University of Singapore's Department of Political Science, who researches local governments in China. For instance, several senior officials in Beijing and Yunnan were replaced after a resurgence of Covid-19 cases late last year and earlier this year.

"In the actual implementation process, local officials need to strike a balance between what the upper levels expect and what they can deliver with the resources at their disposal," Prof Gao told The Straits Times. "Sometimes, the manner in which grassroots-level officials implement the policies paradoxically undermines the national goal."

https://www.straitstimes.com/asia/east-asia/china-to-approve-mrna-vaccine-soon

 

Better still....Pfizer shld rename the china-bound vaccines as Great Wall BNT888!

 

[Kb27]

Antibodies from Sinovac's Covid-19 shot fade after 6 months, booster helps: Chinese study

BEIJING (REUTERS) - Antibodies triggered by Sinovac Biotech’s Covid-19 vaccine declined below a key threshold from around six months after a second dose for most recipients, but a third shot had a strong booster effect, a lab study showed.

Chinese researchers reported the findings from a study of blood samples from healthy adults aged between 18 and 59 in a paper published on Sunday (July 25), which has not been peer reviewed.

Among participants who received two doses, two or four weeks apart, only 16.9 per cent and 35.2 per cent respectively still had neutralising antibodies above what researchers regard as a detectable threshold level six months after the second shot, the paper said.

Those readings was based on data from two cohorts involving more than 50 participants each, while the study gave third doses to a total of 540 participants.

Researchers said it was unclear how the decrease in antibodies would affect the shot’s effectiveness, since scientists have yet to figure out precisely the threshold of antibody levels for a vaccine to be able to prevent the disease.

Apart from durable antibodies, other components in humans immune systems such as T cells and B cell memory elicited by the vaccine may also contribute to protection, researchers involved in the study said, although the study did not provide data on those factors.

 

 

yeap, you need more boosters, like every 6 months.

[Vinyl]

Our MCF vaccine expert shitting on Chinese vaccines should take a look at this. When it comes to Pfizer / Moderna suddenly constipation? Cannot pang sai already?

 

 

[Volvobrick]

Yeah already almost concluded that vaccines won't prevent infection nor infecting others for Delta variant, only reduce the severity. 

Get vaccinated for ourselves, not for others.