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Let's talk about Vaccine Booster Shots

therock

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therock

therock

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https://www.straitstimes.com/singapore/health/pace-of-reopening-amid-covid-19-depends-on-price-singapore-is-willing-to-pay-say

 

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SINGAPORE - How Singapore moves forward in dealing and living with Covid-19 depends on the price the country is willing to pay to achieve this.

There is no perfect option and it is a matter of choosing "the best set of trade-offs that we would wish to have", said Associate Professor Hsu Li Yang, an infectious diseases expert at the NUS Saw Swee Hock School of Public Health.

He was one of three panellists at The Straits Times discussion, Living With Covid-19: When And How?, on Thursday (Sept 16).

Prof Hsu said severe illness and deaths will rise as measures ease, but aiming for no deaths means the constraints on society will be extremely high: "We haven't talked about what we might want to accept in terms of the cost of living with Covid-19."

Singapore has close to 75,000 Covid-19 cases, of whom 59 people have died. There are now 77 people seriously ill and 12 in critical condition.

The nation can open up faster if it is willing to accept six or seven deaths a day. It may not be able to do that if it wants to keep the death toll closer to what one sees for influenza, which is two a day, he said.

Professor Ooi Eng Eong of Duke-NUS Medical School said at the discussion that Singapore's ability to keeps deaths to less than 0.1 per cent - when in some countries the rate is as high as 3 per cent - is "extremely remarkable".

But the strict mitigating measures do cause other problems. To keep hospital beds free for Covid-19 patients, a lot of non-urgent treatments are being postponed.

Said Prof Ooi: "Someone who needs a hip replacement because they can't walk - if we have to delay that, what would that do to their cardiovascular health when they cannot exercise?"

There are also non-health costs, he said.

"Our children are growing up in a situation where going to school is just about education. There's no play, and play is so important in growing up.

"Part of the benefits of university education is that you form this network that then carries you through your career. Our university students have been stuck at home for a year-and-a-half, so what's that going to do to the future of our next generation?"

 

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Ender

Ender

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2 hours ago, 13177 said:

Definitely will go for the same vaccine if little or not much side effects for the first 2 doses. If have many side effects even they are not serious also sian half to take the same vaccine again. Surely i would not want to take again if have too many side effects before. Lol.

Li pak jiam buay?

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Ender

Ender

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3 hours ago, Kb27 said:

 That sounds like the "superhuman" or "hybrid" immunity in reverse, Get natural immunity and vaccinated immunity - both in whichever order.

 

https://news.yahoo.com/evidence-superhuman-immunity-covid-19-092149813.html

It's being dubbed 'superhuman immunity'.

New research shows some people may have a significantly higher level of immunity to COVID-19 that could even protect them from future pandemics.

Scientists studied individuals who have recovered from the virus and then later received a mRNA vaccine, such as Pfizer or Moderna.

What they found was that protection against the disease and its variants was higher than immunity conferred by either infection alone or vaccine alone.

Paul Bieniasz is a virologist at the Rockefeller University, he prefers the term hybrid, rather than superhuman immunity:

"So this is a phenomenon that we and others have uncovered in people who were infected by SARS-CoV-2 early in the pandemic, and then some months later when vaccines became available, they were vaccinated."

"..Their antibodies were not only capable of neutralizing all of the SARS-CoV-2 variants that we have seen thus far, they're also capable of neutralizing viruses that are very much more diverse, including the original SARS coronavirus, which is really quite different to the current ones, viruses that are currently circulating in bats and pangolins..."

Ya, got read before natural immunity first then get vaccinated immunity before will give powerful hybrid immunity. But this Singapore prof is the first I've read to mention the reverse order also give good hybrid immunity.

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Ender

Ender

Hypersonic
5 hours ago, Kb27 said:

I take COVID vaccine bcuz it's free. [laugh]

Last time dr in polyclinic ask me to take 3 shots hep B, vaccine. wah..it got very expensive. The 3rd booster shot I missed it.

Most health screening package will include test for the presence of this hep b virus. So for peace of mind, can test for it.

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Kb27

Kb27

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4 hours ago, Ender said:

Can choose either mRNA, no need to jab the same vaccine as the previous two shot.

 

https://sg.news.yahoo.com/covid-booster-pfizer-biontech-moderna-vaccine-134827443.html

COVID booster: Pfizer or Moderna vaccines interchangeable

I choose the one nearest my home and it's still Comirnaty. Unless I'm willing to go out of my way to look for Moderna.

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Ender

Ender

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(edited)

According to experts, booster shot not neccessary for most under 60s. Also too many boost is not good, your body might get used to it.

https://www.todayonline.com/singapore/explainer-covid-19-vaccine-booster-shots-are-they-really-necessary-everyone


 

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Dr Leong Hoe Nam from Rophi Clinic at Mount Elizabeth Novena Specialist Centre is of the view that vaccine boosters should be used whenever it can reduce deaths or serious illnesses.

He finds the decision to give boosters to seniors aged 60 and above “a rather rough tool”.

Although he recognises that a booster will help a diabetic suffering from kidney failure, it is “unlikely to really benefit” a 69-year-old man with no history of chronic illnesses.

So, for those aged 60 and under, Dr Leong does not think that the benefit of preventing infection or severe illness with a booster shot is “worth it”.

“Should the vaccines be donated to other countries (that need them more)?

“The data for those healthy and under 60 years old is unclear. No deaths have occurred in this group yet. I cannot advocate for this group since there is no data.”

In the meantime, he warns against taking booster jabs too often because the body may treat the vaccine as "self", learn to tolerate it and then not respond to fight the virus.

“That would be the greatest disaster. The body’s immune system would then ‘welcome’ the real infection with no resistance,” he said. 

 


 

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Jman888

Jman888

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1 minute ago, Fitvip said:

So, When invited to go for booster, go or don't go?😕

 below 60 yo won't be invited, above 60 unless you can run 2.4 in 7min, if not better take [laugh]

 

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Fitvip

Fitvip

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2 minutes ago, Jman888 said:

 below 60 yo won't be invited, above 60 unless you can run 2.4 in 7min, if not better take [laugh]

 

So will have to race with Soh Rui Yong first?😀

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Beanoyip

Beanoyip

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On 9/16/2021 at 1:30 PM, inlinesix said:

If flu vaccine is required every year in temperate countries, COVID19 vaccine is no different from that.

The ONLY problem is WE DON'T TAKE FLU VACCINE YEARLY.

Not in SG at least.. countries with winter take the flu vaccine yearly.. not compulsory though.

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therock

therock

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https://www.straitstimes.com/world/united-states/johnson-johnsons-covid-19-booster-shot-prevents-severe-infection

 

NEW YORK (BLOOMBERG) - A booster dose of Johnson & Johnson's Covid-19 vaccine provided 100 per cent protection against severe disease when given two months after the first inoculation, according to widely anticipated data that suggests it increases the potency of the one-time shot.

The booster was 94 per cent effective at preventing symptomatic Covid infections in the US portion of the Phase III trial, and 75 per cent effective overall when it was given 56 days after the initial dose, the company said in a statement.

A second study found the additional shot spurred a 12-fold increase in production of antibodies against Covid when it was given six months after the first.

The results come as many developed nations turn to booster shots to address waning protection from some vaccines and the rise of the more infectious Delta variant, which is sparking new outbreaks globally.

The move has raised questions about the level of protection afforded by the existing shots and the equitable distribution of the vaccines now available.

"Our single-shot vaccine generates strong immune responses and long-lasting immune memory," said Dr Mathai Mammen, global head of research and development for Johnson & Johnson's Janssen drug unit, in the statement.

"When a booster of the Johnson & Johnson Covid-19 vaccine is given, the strength of protection against Covid-19 further increases."

The time period between the initial vaccine and the booster shot was significant, the research showed.

When the second dose was given two months after the first shot, it triggered a four-to-six fold increase in antibody levels - less than the 12-fold gain seen when it was given six months after the initial injection.

Most vaccinated Americans have received the potent two-dose messenger RNA vaccines made by Pfizer Inc and BioNTech SE, or Moderna Inc, with a smaller group getting J&J's single shot inoculation.

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